What Are the Cutoff Levels for a DOT Oral Fluid Drug Test?

DOT oral fluid drug test cutoff levels are set in Table 1 to 49 CFR 40.91, with one cutoff for the initial test and one for the confirmatory test. All values are in nanograms per milliliter (ng/mL).

• Marijuana (THC): 4 initial, 2 confirmatory
• Cocaine and benzoylecgonine: 15 initial, 8 confirmatory
• Codeine and morphine: 30 initial, 15 confirmatory
• Hydrocodone and hydromorphone: 30 initial, 15 confirmatory
• Oxycodone and oxymorphone: 30 initial, 15 confirmatory
• 6-Acetylmorphine: 4 initial, 2 confirmatory
• Phencyclidine (PCP): 10 initial, 10 confirmatory
• Amphetamine and methamphetamine: 50 initial, 25 confirmatory
• MDMA and MDA: 50 initial, 25 confirmatory

The oral fluid table tests for THC itself rather than the THCA metabolite used in urine testing. A footnote states that when a laboratory uses an alternate technology initial test that is specific for THC or 6-acetylmorphine, the confirmatory cutoff of 2 ng/mL applies to the initial test as well.

Under 49 CFR 40.97(g), a laboratory provides quantitative values for confirmed positive morphine or codeine oral fluid results at or below 150 ng/mL. The HHS list of certified laboratories published in the Federal Register on September 30, 2026 states that no laboratories were certified at that time to test oral fluid specimens. When oral fluid can be used is covered in What Types of Drug Tests Are Allowed under DOT Rules?. Urine cutoffs are covered in What Are the Cutoff Levels for a DOT Urine Drug Test?.

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